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For the first time, scientists have identified the activity of a metabolic enzyme found in the batteries of human skin cells declines with age, an advance that may lead to powerful anti-aging treatments.
A Newcastle University study, published online in the Journal of Investigative Dermatology, has found that the activity of mitochondrial complex II significantly decreases in older skin.
This discovery brings experts a step closer to developing powerful anti-aging treatments and cosmetic products which may be tailored to counteract the decline in the enzyme's activity levels, researchers said.
The findings may also lead to a greater understanding of how other organs in the body age, which could pave the way for drug developments in a number of age-related diseases, including cancer.
As our bodies age, we see that the batteries in our cells run down, known as decreased bio-energy, and harmful free radicals increase," said Mark Birch-Machin, Professor of Molecular Dermatology at Newcastle University, who led the study with Dr Amy Bowman. "We now have a specific biomarker, or a target, for developing and screening anti-aging treatments and cosmetic creams that may counter this decline in bio-energy" Birch-Machin said.

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