A
Team led by an Indian origin scientist has identified
a group of little explored cancer cells that may play a
key role in preventing the progression of the disease .It
could lead to re -evaluation of common treatments for
patients. It also suggested that anti -angiogenic therapies
that targets those tum our cells -called pericytes- may
inadvertently be making tumours more aggressive and likely
to spread..Advance drugs shrinks tumour by cutting of their
blood supply, but in doing so they wipe out pericytes that
provide structural support to blood vessels and act as
'gatekeepers 'to pen in cancer.
Conducted in Beth Israel Deaconess Medical Center in Boston, the study highlights the importance of more research on tumour cells composition in order to device more effective therapies, the researchers said.
Not everything present on tumour is bad for us pericyte functionality and coverage on blood vessels is important because it allows the blood vessels to be leak free and normal .Was stated by author Raghu Kalluri , a professor of medicine at Harvard Medical School.The implication of this study shows how today's practice of targeting pericyte as a form of treatment may come at a price ,Kalluri explained .
For the study , Kalluri and his team created genetically modified mice to support drug -induced depletion of pericytes in growing tumours .They then deleted pericytes in their cancer tumours ., reducing pericyte number by 60%.
Compared with wild type controls , they saw a 30% decrease in tumour volumes over 25 days .
This study published in the journal Cancer cells.
Conducted in Beth Israel Deaconess Medical Center in Boston, the study highlights the importance of more research on tumour cells composition in order to device more effective therapies, the researchers said.
Not everything present on tumour is bad for us pericyte functionality and coverage on blood vessels is important because it allows the blood vessels to be leak free and normal .Was stated by author Raghu Kalluri , a professor of medicine at Harvard Medical School.The implication of this study shows how today's practice of targeting pericyte as a form of treatment may come at a price ,Kalluri explained .
For the study , Kalluri and his team created genetically modified mice to support drug -induced depletion of pericytes in growing tumours .They then deleted pericytes in their cancer tumours ., reducing pericyte number by 60%.
Compared with wild type controls , they saw a 30% decrease in tumour volumes over 25 days .
This study published in the journal Cancer cells.
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