FOR THE first time scientist led by an Indian -origin researcher have successfully replaced a major blood vessel in a 10 year old girl with a vein grown in a lab using her own stem cells.
The pioneering transplant publish in The Lancet, marks a further advance in growing body parts in laboratory. and offer hopes for patients who lack suitable veins for dialysis or by pass surgery.In the landmark research,a team from the University of the Gothenburg in sweden took a vein from a dead man ,stripped of its own cells and then bathed in stem cell from the girl,who was suffering from portal vein obstruction.
There was a " striking " improvement in her quality of life after the transplantation,Professor Suchitra
The hepatic portal vein drains the blood from the intestines and spleen to the lever.The blockage can cause serious complications like lethal variceal bleeding ,enlarge spleen ,developmental retardation,and even death.To date attempts to restore portal blood flow using umbilical veins and artificial grafts to build a bridge around the blockage(called meso Rex bypass) have had mixed success.
The Sweden team took a 9cm stem segment of iliac(groin) from the dead donar and removed all living cells ,leaving a tube consisting of just the protein scaffolding .This scaffolding was injected with stem cells obtain from the girl's bone marrow.Two weeks after seeding ,the graft was re -implanted during a meso-Rex by pass procedure.
The girl had no complications from the operation and normal blood flow was immediately restore.In the year after the operation the girl gained good height and weight .But a year after the procedure ,decreased portal blood flow was noted and narrowing of the graft required second stem cell -based graft to be done .Since she has remained well and can walk long distances she has not developed anti donor anti bodies despite not talking immuno suppressive drugs".The new stem cell drived graft resulted not only in good blood flow rates and normal laboratory tests values but also, in strikingly improved quality of life for the patient" the reasearches concluded.
The work also establishes the feasibility and safety of a novel paradigm for treatment .In cases of venous insuffieciency obstructed veins or inadequate autologous veins .Further it opens new areas of research ,including trying to reproduce artries for surgical use in patients with arteriovenous fistuals for dialysis (a type of vascular access for dialysis) or" coronary bypass surgery".
STEM CELLS -
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The pioneering transplant publish in The Lancet, marks a further advance in growing body parts in laboratory. and offer hopes for patients who lack suitable veins for dialysis or by pass surgery.In the landmark research,a team from the University of the Gothenburg in sweden took a vein from a dead man ,stripped of its own cells and then bathed in stem cell from the girl,who was suffering from portal vein obstruction.
There was a " striking " improvement in her quality of life after the transplantation,Professor Suchitra
The hepatic portal vein drains the blood from the intestines and spleen to the lever.The blockage can cause serious complications like lethal variceal bleeding ,enlarge spleen ,developmental retardation,and even death.To date attempts to restore portal blood flow using umbilical veins and artificial grafts to build a bridge around the blockage(called meso Rex bypass) have had mixed success.
The Sweden team took a 9cm stem segment of iliac(groin) from the dead donar and removed all living cells ,leaving a tube consisting of just the protein scaffolding .This scaffolding was injected with stem cells obtain from the girl's bone marrow.Two weeks after seeding ,the graft was re -implanted during a meso-Rex by pass procedure.
The girl had no complications from the operation and normal blood flow was immediately restore.In the year after the operation the girl gained good height and weight .But a year after the procedure ,decreased portal blood flow was noted and narrowing of the graft required second stem cell -based graft to be done .Since she has remained well and can walk long distances she has not developed anti donor anti bodies despite not talking immuno suppressive drugs".The new stem cell drived graft resulted not only in good blood flow rates and normal laboratory tests values but also, in strikingly improved quality of life for the patient" the reasearches concluded.
The work also establishes the feasibility and safety of a novel paradigm for treatment .In cases of venous insuffieciency obstructed veins or inadequate autologous veins .Further it opens new areas of research ,including trying to reproduce artries for surgical use in patients with arteriovenous fistuals for dialysis (a type of vascular access for dialysis) or" coronary bypass surgery".
STEM CELLS -
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