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NEW FINDINGS-FOUND CELL .THAT CAN HELP PREVENT CANCER.

A  Team    led  by   an  Indian   origin   scientist   has  identified   a  group  of little  explored   cancer  cells   that  may  play  a     key  role  in  preventing  the   progression   of   the  disease   .It   could  lead  to  re -evaluation    of  common  treatments  for patients.  It   also  suggested  that    anti -angiogenic   therapies  that   targets  those   tum our  cells   -called  pericytes-   may  inadvertently   be making  tumours  more   aggressive   and  likely   to  spread..Advance  drugs  shrinks  tumour   by  cutting   of  their   blood  supply,  but in  doing  so  they  wipe out  pericytes  that  provide  structural  support   to  blood  vessels  and  act   as   'gatekeepers  'to  pen  in  cancer.
Conducted  in  Beth  Israel  Deaconess  Medical  Center   in   Boston, the  study  highlights   the  importance  of more  research  on   tumour  cells  composition  in  order to  device   more   effective  therapies,  the  researchers   said.
Not  everything  present  on  tumour   is  bad  for  us  pericyte  functionality   and  coverage  on   blood  vessels  is important  because  it  allows  the  blood  vessels   to  be  leak  free   and  normal .Was    stated   by  author  Raghu  Kalluri ,  a  professor  of  medicine   at    Harvard   Medical  School.The  implication  of  this  study  shows    how  today's  practice   of  targeting  pericyte   as  a  form of    treatment   may  come  at a  price ,Kalluri  explained .
For  the   study  , Kalluri  and  his  team    created  genetically   modified  mice  to  support   drug  -induced  depletion   of  pericytes in   growing  tumours  .They  then  deleted     pericytes   in  their  cancer  tumours ., reducing  pericyte     number  by  60%.
Compared   with  wild  type   controls , they  saw   a  30%  decrease in   tumour   volumes over  25   days .
This    study   published    in  the  journal  Cancer   cells.



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